Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines

The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-ar...

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Autores principales: Mphahlele, Malose Jack, Paumo, Hugues Kadem, El-Nahas, Ahmed M., El-Hendawy, Morad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271842/
https://www.ncbi.nlm.nih.gov/pubmed/24434693
http://dx.doi.org/10.3390/molecules19010795
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author Mphahlele, Malose Jack
Paumo, Hugues Kadem
El-Nahas, Ahmed M.
El-Hendawy, Morad M.
author_facet Mphahlele, Malose Jack
Paumo, Hugues Kadem
El-Nahas, Ahmed M.
El-Hendawy, Morad M.
author_sort Mphahlele, Malose Jack
collection PubMed
description The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic acids occurred without selectivity to afford the corresponding 2,6,8-triaryl-4-(phenylethynyl)quinazolines. The absorption and emission properties of these polysubstituted quinazolines were also determined.
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spelling pubmed-62718422018-12-20 Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines Mphahlele, Malose Jack Paumo, Hugues Kadem El-Nahas, Ahmed M. El-Hendawy, Morad M. Molecules Article The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic acids occurred without selectivity to afford the corresponding 2,6,8-triaryl-4-(phenylethynyl)quinazolines. The absorption and emission properties of these polysubstituted quinazolines were also determined. MDPI 2014-01-10 /pmc/articles/PMC6271842/ /pubmed/24434693 http://dx.doi.org/10.3390/molecules19010795 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mphahlele, Malose Jack
Paumo, Hugues Kadem
El-Nahas, Ahmed M.
El-Hendawy, Morad M.
Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
title Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
title_full Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
title_fullStr Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
title_full_unstemmed Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
title_short Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
title_sort synthesis and photophysical property studies of the 2,6,8-triaryl-4-(phenylethynyl)quinazolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271842/
https://www.ncbi.nlm.nih.gov/pubmed/24434693
http://dx.doi.org/10.3390/molecules19010795
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