Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines

Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for thei...

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Autores principales: Montana, Marc, Correard, Florian, Khoumeri, Omar, Esteve, Marie-Anne, Terme, Thierry, Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271844/
https://www.ncbi.nlm.nih.gov/pubmed/25237753
http://dx.doi.org/10.3390/molecules190914987
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author Montana, Marc
Correard, Florian
Khoumeri, Omar
Esteve, Marie-Anne
Terme, Thierry
Vanelle, Patrice
author_facet Montana, Marc
Correard, Florian
Khoumeri, Omar
Esteve, Marie-Anne
Terme, Thierry
Vanelle, Patrice
author_sort Montana, Marc
collection PubMed
description Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities.
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spelling pubmed-62718442018-12-27 Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines Montana, Marc Correard, Florian Khoumeri, Omar Esteve, Marie-Anne Terme, Thierry Vanelle, Patrice Molecules Article Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities. MDPI 2014-09-18 /pmc/articles/PMC6271844/ /pubmed/25237753 http://dx.doi.org/10.3390/molecules190914987 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Montana, Marc
Correard, Florian
Khoumeri, Omar
Esteve, Marie-Anne
Terme, Thierry
Vanelle, Patrice
Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines
title Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines
title_full Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines
title_fullStr Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines
title_full_unstemmed Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines
title_short Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines
title_sort synthesis of new quinoxalines containing an oxirane ring by the tdae strategy and in vitro evaluation in neuroblastoma cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271844/
https://www.ncbi.nlm.nih.gov/pubmed/25237753
http://dx.doi.org/10.3390/molecules190914987
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