Cargando…
Antifungal Plant Defensins: Mechanisms of Action and Production
Plant defensins are small, cysteine-rich peptides that possess biological activity towards a broad range of organisms. Their activity is primarily directed against fungi, but bactericidal and insecticidal actions have also been reported. The mode of action of various antifungal plant defensins has b...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271847/ https://www.ncbi.nlm.nih.gov/pubmed/25153857 http://dx.doi.org/10.3390/molecules190812280 |
_version_ | 1783377021596860416 |
---|---|
author | Vriens, Kim Cammue, Bruno P. A. Thevissen, Karin |
author_facet | Vriens, Kim Cammue, Bruno P. A. Thevissen, Karin |
author_sort | Vriens, Kim |
collection | PubMed |
description | Plant defensins are small, cysteine-rich peptides that possess biological activity towards a broad range of organisms. Their activity is primarily directed against fungi, but bactericidal and insecticidal actions have also been reported. The mode of action of various antifungal plant defensins has been studied extensively during the last decades and several of their fungal targets have been identified to date. This review summarizes the mechanism of action of well-characterized antifungal plant defensins, including RsAFP2, MsDef1, MtDef4, NaD1 and Psd1, and points out the variety by which antifungal plant defensins affect microbial cell viability. Furthermore, this review summarizes production routes for plant defensins, either via heterologous expression or chemical synthesis. As plant defensins are generally considered non-toxic for plant and mammalian cells, they are regarded as attractive candidates for further development into novel antimicrobial agents. |
format | Online Article Text |
id | pubmed-6271847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62718472018-12-27 Antifungal Plant Defensins: Mechanisms of Action and Production Vriens, Kim Cammue, Bruno P. A. Thevissen, Karin Molecules Review Plant defensins are small, cysteine-rich peptides that possess biological activity towards a broad range of organisms. Their activity is primarily directed against fungi, but bactericidal and insecticidal actions have also been reported. The mode of action of various antifungal plant defensins has been studied extensively during the last decades and several of their fungal targets have been identified to date. This review summarizes the mechanism of action of well-characterized antifungal plant defensins, including RsAFP2, MsDef1, MtDef4, NaD1 and Psd1, and points out the variety by which antifungal plant defensins affect microbial cell viability. Furthermore, this review summarizes production routes for plant defensins, either via heterologous expression or chemical synthesis. As plant defensins are generally considered non-toxic for plant and mammalian cells, they are regarded as attractive candidates for further development into novel antimicrobial agents. MDPI 2014-08-14 /pmc/articles/PMC6271847/ /pubmed/25153857 http://dx.doi.org/10.3390/molecules190812280 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Vriens, Kim Cammue, Bruno P. A. Thevissen, Karin Antifungal Plant Defensins: Mechanisms of Action and Production |
title | Antifungal Plant Defensins: Mechanisms of Action and Production |
title_full | Antifungal Plant Defensins: Mechanisms of Action and Production |
title_fullStr | Antifungal Plant Defensins: Mechanisms of Action and Production |
title_full_unstemmed | Antifungal Plant Defensins: Mechanisms of Action and Production |
title_short | Antifungal Plant Defensins: Mechanisms of Action and Production |
title_sort | antifungal plant defensins: mechanisms of action and production |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271847/ https://www.ncbi.nlm.nih.gov/pubmed/25153857 http://dx.doi.org/10.3390/molecules190812280 |
work_keys_str_mv | AT vrienskim antifungalplantdefensinsmechanismsofactionandproduction AT cammuebrunopa antifungalplantdefensinsmechanismsofactionandproduction AT thevissenkarin antifungalplantdefensinsmechanismsofactionandproduction |