Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spect...

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Detalles Bibliográficos
Autores principales: Yang, Bing-You, Guo, Rui, Li, Ting, Liu, Yan, Wang, Chang-Fu, Shu, Zun-Peng, Wang, Zhi-Bin, Zhang, Jing, Xia, Yong-Gang, Jiang, Hai, Wang, Qiu-Hong, Kuang, Hai-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271864/
https://www.ncbi.nlm.nih.gov/pubmed/24731984
http://dx.doi.org/10.3390/molecules19044548
Descripción
Sumario:Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC(50) values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively.

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