Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spect...

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Autores principales: Yang, Bing-You, Guo, Rui, Li, Ting, Liu, Yan, Wang, Chang-Fu, Shu, Zun-Peng, Wang, Zhi-Bin, Zhang, Jing, Xia, Yong-Gang, Jiang, Hai, Wang, Qiu-Hong, Kuang, Hai-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271864/
https://www.ncbi.nlm.nih.gov/pubmed/24731984
http://dx.doi.org/10.3390/molecules19044548
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author Yang, Bing-You
Guo, Rui
Li, Ting
Liu, Yan
Wang, Chang-Fu
Shu, Zun-Peng
Wang, Zhi-Bin
Zhang, Jing
Xia, Yong-Gang
Jiang, Hai
Wang, Qiu-Hong
Kuang, Hai-Xue
author_facet Yang, Bing-You
Guo, Rui
Li, Ting
Liu, Yan
Wang, Chang-Fu
Shu, Zun-Peng
Wang, Zhi-Bin
Zhang, Jing
Xia, Yong-Gang
Jiang, Hai
Wang, Qiu-Hong
Kuang, Hai-Xue
author_sort Yang, Bing-You
collection PubMed
description Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC(50) values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively.
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spelling pubmed-62718642019-01-02 Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production Yang, Bing-You Guo, Rui Li, Ting Liu, Yan Wang, Chang-Fu Shu, Zun-Peng Wang, Zhi-Bin Zhang, Jing Xia, Yong-Gang Jiang, Hai Wang, Qiu-Hong Kuang, Hai-Xue Molecules Article Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC(50) values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively. MDPI 2014-04-11 /pmc/articles/PMC6271864/ /pubmed/24731984 http://dx.doi.org/10.3390/molecules19044548 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Bing-You
Guo, Rui
Li, Ting
Liu, Yan
Wang, Chang-Fu
Shu, Zun-Peng
Wang, Zhi-Bin
Zhang, Jing
Xia, Yong-Gang
Jiang, Hai
Wang, Qiu-Hong
Kuang, Hai-Xue
Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
title Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
title_full Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
title_fullStr Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
title_full_unstemmed Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
title_short Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
title_sort five withanolides from the leaves of datura metel l. and their inhibitory effects on nitric oxide production
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271864/
https://www.ncbi.nlm.nih.gov/pubmed/24731984
http://dx.doi.org/10.3390/molecules19044548
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