Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents

By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtain...

Descripción completa

Detalles Bibliográficos
Autores principales: Giovine, Arianna, Muraglia, Marilena, Florio, Marco Antonio, Rosato, Antonio, Corbo, Filomena, Franchini, Carlo, Musio, Biagia, Degennaro, Leonardo, Luisi, Renzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271868/
https://www.ncbi.nlm.nih.gov/pubmed/25093988
http://dx.doi.org/10.3390/molecules190811505
_version_ 1783377026528313344
author Giovine, Arianna
Muraglia, Marilena
Florio, Marco Antonio
Rosato, Antonio
Corbo, Filomena
Franchini, Carlo
Musio, Biagia
Degennaro, Leonardo
Luisi, Renzo
author_facet Giovine, Arianna
Muraglia, Marilena
Florio, Marco Antonio
Rosato, Antonio
Corbo, Filomena
Franchini, Carlo
Musio, Biagia
Degennaro, Leonardo
Luisi, Renzo
author_sort Giovine, Arianna
collection PubMed
description By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.
format Online
Article
Text
id pubmed-6271868
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62718682018-12-27 Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents Giovine, Arianna Muraglia, Marilena Florio, Marco Antonio Rosato, Antonio Corbo, Filomena Franchini, Carlo Musio, Biagia Degennaro, Leonardo Luisi, Renzo Molecules Article By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included. MDPI 2014-08-04 /pmc/articles/PMC6271868/ /pubmed/25093988 http://dx.doi.org/10.3390/molecules190811505 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Giovine, Arianna
Muraglia, Marilena
Florio, Marco Antonio
Rosato, Antonio
Corbo, Filomena
Franchini, Carlo
Musio, Biagia
Degennaro, Leonardo
Luisi, Renzo
Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_full Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_fullStr Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_full_unstemmed Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_short Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_sort synthesis of functionalized arylaziridines as potential antimicrobial agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271868/
https://www.ncbi.nlm.nih.gov/pubmed/25093988
http://dx.doi.org/10.3390/molecules190811505
work_keys_str_mv AT giovinearianna synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT muragliamarilena synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT floriomarcoantonio synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT rosatoantonio synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT corbofilomena synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT franchinicarlo synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT musiobiagia synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT degennaroleonardo synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents
AT luisirenzo synthesisoffunctionalizedarylaziridinesaspotentialantimicrobialagents

Ejemplares similares