Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya

Two new sesquiterpenoids with guaiane skeletons—holosericin A (1) and holosericin B (2)—were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated...

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Detalles Bibliográficos
Autores principales: Ma, Qing-Yun, Chen, Yi-Chun, Huang, Sheng-Zhuo, Guo, Zhi-Kai, Dai, Hao-Fu, Hua, Yan, Zhao, You-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271883/
https://www.ncbi.nlm.nih.gov/pubmed/25215585
http://dx.doi.org/10.3390/molecules190914266
Descripción
Sumario:Two new sesquiterpenoids with guaiane skeletons—holosericin A (1) and holosericin B (2)—were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.

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