Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya

Two new sesquiterpenoids with guaiane skeletons—holosericin A (1) and holosericin B (2)—were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated...

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Autores principales: Ma, Qing-Yun, Chen, Yi-Chun, Huang, Sheng-Zhuo, Guo, Zhi-Kai, Dai, Hao-Fu, Hua, Yan, Zhao, You-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271883/
https://www.ncbi.nlm.nih.gov/pubmed/25215585
http://dx.doi.org/10.3390/molecules190914266
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author Ma, Qing-Yun
Chen, Yi-Chun
Huang, Sheng-Zhuo
Guo, Zhi-Kai
Dai, Hao-Fu
Hua, Yan
Zhao, You-Xing
author_facet Ma, Qing-Yun
Chen, Yi-Chun
Huang, Sheng-Zhuo
Guo, Zhi-Kai
Dai, Hao-Fu
Hua, Yan
Zhao, You-Xing
author_sort Ma, Qing-Yun
collection PubMed
description Two new sesquiterpenoids with guaiane skeletons—holosericin A (1) and holosericin B (2)—were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.
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spelling pubmed-62718832018-12-27 Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya Ma, Qing-Yun Chen, Yi-Chun Huang, Sheng-Zhuo Guo, Zhi-Kai Dai, Hao-Fu Hua, Yan Zhao, You-Xing Molecules Article Two new sesquiterpenoids with guaiane skeletons—holosericin A (1) and holosericin B (2)—were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition. MDPI 2014-09-11 /pmc/articles/PMC6271883/ /pubmed/25215585 http://dx.doi.org/10.3390/molecules190914266 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ma, Qing-Yun
Chen, Yi-Chun
Huang, Sheng-Zhuo
Guo, Zhi-Kai
Dai, Hao-Fu
Hua, Yan
Zhao, You-Xing
Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya
title Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya
title_full Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya
title_fullStr Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya
title_full_unstemmed Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya
title_short Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya
title_sort two new guaiane sesquiterpenoids from daphne holosericea (diels) hamaya
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271883/
https://www.ncbi.nlm.nih.gov/pubmed/25215585
http://dx.doi.org/10.3390/molecules190914266
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