In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these m...

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Detalles Bibliográficos
Autores principales: Nunes, Geandra B. L., Policarpo, Paola R., Costa, Luciana M., da Silva, Teresinha G., Militão, Gardenia Carmen G., Câmara, Celso A., Filho, José Maria Barbosa, Gutierrez, Stanley Juan C., Islam, Mohammed T., de Freitas, Rivelilson M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271893/
https://www.ncbi.nlm.nih.gov/pubmed/24731987
http://dx.doi.org/10.3390/molecules19044595
Descripción
Sumario:This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.

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