Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh

Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O-[4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-d-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O-galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucos...

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Detalles Bibliográficos
Autores principales: Huang, Doudou, Jiang, Yun, Chen, Wansheng, Yao, Fengyan, Sun, Lianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271895/
https://www.ncbi.nlm.nih.gov/pubmed/25076141
http://dx.doi.org/10.3390/molecules190811045
Descripción
Sumario:Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O-[4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-d-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O-galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC(50) values of 12.7 and 19.2 μM, respectively.

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