Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh

Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O-[4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-d-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O-galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucos...

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Detalles Bibliográficos
Autores principales: Huang, Doudou, Jiang, Yun, Chen, Wansheng, Yao, Fengyan, Sun, Lianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271895/
https://www.ncbi.nlm.nih.gov/pubmed/25076141
http://dx.doi.org/10.3390/molecules190811045
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author Huang, Doudou
Jiang, Yun
Chen, Wansheng
Yao, Fengyan
Sun, Lianna
author_facet Huang, Doudou
Jiang, Yun
Chen, Wansheng
Yao, Fengyan
Sun, Lianna
author_sort Huang, Doudou
collection PubMed
description Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O-[4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-d-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O-galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC(50) values of 12.7 and 19.2 μM, respectively.
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spelling pubmed-62718952018-12-27 Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh Huang, Doudou Jiang, Yun Chen, Wansheng Yao, Fengyan Sun, Lianna Molecules Article Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O-[4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-d-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O-galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC(50) values of 12.7 and 19.2 μM, respectively. MDPI 2014-07-29 /pmc/articles/PMC6271895/ /pubmed/25076141 http://dx.doi.org/10.3390/molecules190811045 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Doudou
Jiang, Yun
Chen, Wansheng
Yao, Fengyan
Sun, Lianna
Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh
title Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh
title_full Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh
title_fullStr Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh
title_full_unstemmed Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh
title_short Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh
title_sort polyphenols with anti-proliferative activities from penthorum chinense pursh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271895/
https://www.ncbi.nlm.nih.gov/pubmed/25076141
http://dx.doi.org/10.3390/molecules190811045
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