Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC(50) values of 1.8, 3.0 and 4.3 µM, respectively. Also, the agl...

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Detalles Bibliográficos
Autores principales: Jang, Myoung-Jun, Kim, Ye Sol, Bae, Eun Young, Oh, Tae-Seok, Choi, Hwa-Jung, Lee, Jung-Hee, Oh, Hyun-Mee, Lee, Seung Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271981/
https://www.ncbi.nlm.nih.gov/pubmed/25486247
http://dx.doi.org/10.3390/molecules191220340
Descripción
Sumario:Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC(50) values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.

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