Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC(50) values of 1.8, 3.0 and 4.3 µM, respectively. Also, the agl...

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Autores principales: Jang, Myoung-Jun, Kim, Ye Sol, Bae, Eun Young, Oh, Tae-Seok, Choi, Hwa-Jung, Lee, Jung-Hee, Oh, Hyun-Mee, Lee, Seung Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271981/
https://www.ncbi.nlm.nih.gov/pubmed/25486247
http://dx.doi.org/10.3390/molecules191220340
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author Jang, Myoung-Jun
Kim, Ye Sol
Bae, Eun Young
Oh, Tae-Seok
Choi, Hwa-Jung
Lee, Jung-Hee
Oh, Hyun-Mee
Lee, Seung Woong
author_facet Jang, Myoung-Jun
Kim, Ye Sol
Bae, Eun Young
Oh, Tae-Seok
Choi, Hwa-Jung
Lee, Jung-Hee
Oh, Hyun-Mee
Lee, Seung Woong
author_sort Jang, Myoung-Jun
collection PubMed
description Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC(50) values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.
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spelling pubmed-62719812018-12-28 Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion Jang, Myoung-Jun Kim, Ye Sol Bae, Eun Young Oh, Tae-Seok Choi, Hwa-Jung Lee, Jung-Hee Oh, Hyun-Mee Lee, Seung Woong Molecules Communication Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC(50) values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation. MDPI 2014-12-04 /pmc/articles/PMC6271981/ /pubmed/25486247 http://dx.doi.org/10.3390/molecules191220340 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Jang, Myoung-Jun
Kim, Ye Sol
Bae, Eun Young
Oh, Tae-Seok
Choi, Hwa-Jung
Lee, Jung-Hee
Oh, Hyun-Mee
Lee, Seung Woong
Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion
title Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion
title_full Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion
title_fullStr Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion
title_full_unstemmed Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion
title_short Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion
title_sort saikosaponin d isolated from bupleurum falcatum inhibits selectin-mediated cell adhesion
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271981/
https://www.ncbi.nlm.nih.gov/pubmed/25486247
http://dx.doi.org/10.3390/molecules191220340
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