Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells

A series of ∆(3)-2-hydroxybakuchiol analogues have been synthesized and tested for their growth inhibitory activity against rat UMR106 cells by using the MTT method. Some of them exhibit enhanced activities compared with the natural product, and the preliminary SAR profile shows that the chain tail...

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Detalles Bibliográficos
Autores principales: Zhao, Qun, Xu, Qianqian, Shan, Guangsheng, Dong, Chao, Zhang, Hong, Lei, Xinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272004/
https://www.ncbi.nlm.nih.gov/pubmed/24561330
http://dx.doi.org/10.3390/molecules19022213
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author Zhao, Qun
Xu, Qianqian
Shan, Guangsheng
Dong, Chao
Zhang, Hong
Lei, Xinsheng
author_facet Zhao, Qun
Xu, Qianqian
Shan, Guangsheng
Dong, Chao
Zhang, Hong
Lei, Xinsheng
author_sort Zhao, Qun
collection PubMed
description A series of ∆(3)-2-hydroxybakuchiol analogues have been synthesized and tested for their growth inhibitory activity against rat UMR106 cells by using the MTT method. Some of them exhibit enhanced activities compared with the natural product, and the preliminary SAR profile shows that the chain tail on the natural product could be subtly modified to enhance the activity and the aromatic moiety or the terminal olefin on the main chain can also be modified without any evident loss of activity. The stereo-configuration of the quaternary chiral center has an important influence on the activity.
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spelling pubmed-62720042018-12-20 Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells Zhao, Qun Xu, Qianqian Shan, Guangsheng Dong, Chao Zhang, Hong Lei, Xinsheng Molecules Article A series of ∆(3)-2-hydroxybakuchiol analogues have been synthesized and tested for their growth inhibitory activity against rat UMR106 cells by using the MTT method. Some of them exhibit enhanced activities compared with the natural product, and the preliminary SAR profile shows that the chain tail on the natural product could be subtly modified to enhance the activity and the aromatic moiety or the terminal olefin on the main chain can also be modified without any evident loss of activity. The stereo-configuration of the quaternary chiral center has an important influence on the activity. MDPI 2014-02-20 /pmc/articles/PMC6272004/ /pubmed/24561330 http://dx.doi.org/10.3390/molecules19022213 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhao, Qun
Xu, Qianqian
Shan, Guangsheng
Dong, Chao
Zhang, Hong
Lei, Xinsheng
Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells
title Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells
title_full Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells
title_fullStr Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells
title_full_unstemmed Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells
title_short Synthesis of ∆(3)-2-Hydroxybakuchiol Analogues and Their Growth Inhibitory Activity against Rat UMR106 Cells
title_sort synthesis of ∆(3)-2-hydroxybakuchiol analogues and their growth inhibitory activity against rat umr106 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272004/
https://www.ncbi.nlm.nih.gov/pubmed/24561330
http://dx.doi.org/10.3390/molecules19022213
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