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Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis

BACKGROUND: Obstructive urolithiasis is a common disease associated with a guarded prognosis in small ruminants. HYPOTHESIS/OBJECTIVE: The results of physical examination, laboratory analyses, and clinical management of male small ruminants presented to 2 referral clinics were investigated to identi...

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Autores principales: Riedi, Anna‐Katharina, Nathues, Christina, Knubben‐Schweizer, Gabriela, Nuss, Karl, Meylan, Mireille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272034/
https://www.ncbi.nlm.nih.gov/pubmed/30307649
http://dx.doi.org/10.1111/jvim.15336
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author Riedi, Anna‐Katharina
Nathues, Christina
Knubben‐Schweizer, Gabriela
Nuss, Karl
Meylan, Mireille
author_facet Riedi, Anna‐Katharina
Nathues, Christina
Knubben‐Schweizer, Gabriela
Nuss, Karl
Meylan, Mireille
author_sort Riedi, Anna‐Katharina
collection PubMed
description BACKGROUND: Obstructive urolithiasis is a common disease associated with a guarded prognosis in small ruminants. HYPOTHESIS/OBJECTIVE: The results of physical examination, laboratory analyses, and clinical management of male small ruminants presented to 2 referral clinics were investigated to identify variables significantly associated with disease outcome, so as to provide better recommendations to animal owners regarding the management of these patients. ANIMALS: Two‐hundred ten small ruminants (130 sheep and 80 goats) with confirmed diagnosis of obstructive urolithiasis. METHODS: Clinical findings (including diagnostic imaging) and laboratory results of the 210 animals were reviewed, and relevant information regarding clinical and laboratory variables recorded upon admission and clinical management was retrieved. The association of the different variables with nonsurvival was investigated by univariable and multivariable logistic regression models. RESULTS: Only 39% of all patients considered for treatment and 52% of those undergoing tube cystostomy survived to be released from the clinic. Nonsurvival was strongly associated with a very poor clinical condition upon presentation, obesity, castration, and evidence of uroperitoneum. Among blood variables, abnormal PCV, severely increased serum creatinine concentrations, and increased activity of the creatine kinase were associated with increased risk of nonsurvival. Presence of signs of colic or macroscopic appearance of urine was not significantly associated with outcome. CONCLUSIONS AND CLINICAL IMPORTANCE: The prognosis of obstructive urolithiasis was guarded with survival rates of 39% (overall) to 52% (after tube cystostomy). Intact young males with normal body condition presented early in the course of disease had the best chances of survival.
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spelling pubmed-62720342018-12-05 Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis Riedi, Anna‐Katharina Nathues, Christina Knubben‐Schweizer, Gabriela Nuss, Karl Meylan, Mireille J Vet Intern Med FOOD & FIBER BACKGROUND: Obstructive urolithiasis is a common disease associated with a guarded prognosis in small ruminants. HYPOTHESIS/OBJECTIVE: The results of physical examination, laboratory analyses, and clinical management of male small ruminants presented to 2 referral clinics were investigated to identify variables significantly associated with disease outcome, so as to provide better recommendations to animal owners regarding the management of these patients. ANIMALS: Two‐hundred ten small ruminants (130 sheep and 80 goats) with confirmed diagnosis of obstructive urolithiasis. METHODS: Clinical findings (including diagnostic imaging) and laboratory results of the 210 animals were reviewed, and relevant information regarding clinical and laboratory variables recorded upon admission and clinical management was retrieved. The association of the different variables with nonsurvival was investigated by univariable and multivariable logistic regression models. RESULTS: Only 39% of all patients considered for treatment and 52% of those undergoing tube cystostomy survived to be released from the clinic. Nonsurvival was strongly associated with a very poor clinical condition upon presentation, obesity, castration, and evidence of uroperitoneum. Among blood variables, abnormal PCV, severely increased serum creatinine concentrations, and increased activity of the creatine kinase were associated with increased risk of nonsurvival. Presence of signs of colic or macroscopic appearance of urine was not significantly associated with outcome. CONCLUSIONS AND CLINICAL IMPORTANCE: The prognosis of obstructive urolithiasis was guarded with survival rates of 39% (overall) to 52% (after tube cystostomy). Intact young males with normal body condition presented early in the course of disease had the best chances of survival. John Wiley & Sons, Inc. 2018-10-11 2018 /pmc/articles/PMC6272034/ /pubmed/30307649 http://dx.doi.org/10.1111/jvim.15336 Text en © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle FOOD & FIBER
Riedi, Anna‐Katharina
Nathues, Christina
Knubben‐Schweizer, Gabriela
Nuss, Karl
Meylan, Mireille
Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis
title Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis
title_full Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis
title_fullStr Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis
title_full_unstemmed Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis
title_short Variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis
title_sort variables of initial examination and clinical management associated with survival in small ruminants with obstructive urolithiasis
topic FOOD & FIBER
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272034/
https://www.ncbi.nlm.nih.gov/pubmed/30307649
http://dx.doi.org/10.1111/jvim.15336
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