RK‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model

Aberrant activation of Wnt/β‐catenin signaling causes tumorigenesis and promotes the proliferation of colorectal cancer cells. Porcupine inhibitors, which block secretion of Wnt ligands, may have only limited clinical impact for the treatment of colorectal cancer, because most colorectal cancer is c...

Descripción completa

Detalles Bibliográficos
Autores principales: Mizutani, Anna, Yashiroda, Yoko, Muramatsu, Yukiko, Yoshida, Haruka, Chikada, Tsubasa, Tsumura, Takeshi, Okue, Masayuki, Shirai, Fumiyuki, Fukami, Takehiro, Yoshida, Minoru, Seimiya, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272098/
https://www.ncbi.nlm.nih.gov/pubmed/30238564
http://dx.doi.org/10.1111/cas.13805

Ejemplares similares

Ejemplares similares