Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond sk...

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Autores principales: Arena, Adriana, Bisignano, Carlo, Stassi, Giovanna, Filocamo, Angela, Mandalari, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272138/
https://www.ncbi.nlm.nih.gov/pubmed/25988612
http://dx.doi.org/10.3390/molecules20058816
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author Arena, Adriana
Bisignano, Carlo
Stassi, Giovanna
Filocamo, Angela
Mandalari, Giuseppina
author_facet Arena, Adriana
Bisignano, Carlo
Stassi, Giovanna
Filocamo, Angela
Mandalari, Giuseppina
author_sort Arena, Adriana
collection PubMed
description We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-α, IFN-γ and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins.
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spelling pubmed-62721382019-01-07 Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network Arena, Adriana Bisignano, Carlo Stassi, Giovanna Filocamo, Angela Mandalari, Giuseppina Molecules Article We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-α, IFN-γ and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins. MDPI 2015-05-15 /pmc/articles/PMC6272138/ /pubmed/25988612 http://dx.doi.org/10.3390/molecules20058816 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arena, Adriana
Bisignano, Carlo
Stassi, Giovanna
Filocamo, Angela
Mandalari, Giuseppina
Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network
title Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network
title_full Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network
title_fullStr Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network
title_full_unstemmed Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network
title_short Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network
title_sort almond skin inhibits hsv-2 replication in peripheral blood mononuclear cells by modulating the cytokine network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272138/
https://www.ncbi.nlm.nih.gov/pubmed/25988612
http://dx.doi.org/10.3390/molecules20058816
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