Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus

A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-b...

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Autores principales: Sparzak, Barbara, Krauze-Baranowska, Mirosława, Kawiak, Anna, Sowiński, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272180/
https://www.ncbi.nlm.nih.gov/pubmed/25942372
http://dx.doi.org/10.3390/molecules20057915
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author Sparzak, Barbara
Krauze-Baranowska, Mirosława
Kawiak, Anna
Sowiński, Paweł
author_facet Sparzak, Barbara
Krauze-Baranowska, Mirosława
Kawiak, Anna
Sowiński, Paweł
author_sort Sparzak, Barbara
collection PubMed
description A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an IC(50) value of 3.8 µg/mL.
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spelling pubmed-62721802019-01-07 Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus Sparzak, Barbara Krauze-Baranowska, Mirosława Kawiak, Anna Sowiński, Paweł Molecules Article A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an IC(50) value of 3.8 µg/mL. MDPI 2015-04-30 /pmc/articles/PMC6272180/ /pubmed/25942372 http://dx.doi.org/10.3390/molecules20057915 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sparzak, Barbara
Krauze-Baranowska, Mirosława
Kawiak, Anna
Sowiński, Paweł
Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus
title Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus
title_full Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus
title_fullStr Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus
title_full_unstemmed Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus
title_short Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus
title_sort cytotoxic lignan from the non-transformed root culture of phyllanthus amarus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272180/
https://www.ncbi.nlm.nih.gov/pubmed/25942372
http://dx.doi.org/10.3390/molecules20057915
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