Synthesis, Structural Characterization and Biological Activity of Novel Cyclohexane-1,3-dione Ligands and Their Metal Complexes

Some new Zn(II) and Cu(II) complexes [Cu(L(1))(OAc)(2)]∙H(2)O, [Cu(L(1))(NO(3))H(2)O]∙NO(3)∙3.5H(2)O, [Zn(L(1))(NO(3))(2)]∙4.5H(2)O, [Zn(L(1))(OAc)(2)(H(2)O)(2)]∙3H(2)O, [Cu(2)(L(2))(OAc)(4)]∙2H(2)O∙2DMF, [Cu(L(2))(2)]∙2NO(3)∙1.5DMF∙H(2)O, [Zn(L(2))(2)(NO(3))(2)]∙DMF and [Zn(2)(L(2))(OAc)(4)(H(2)O)(...

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Detalles Bibliográficos
Autores principales: Turan, Nevin, Körkoca, Hanifi, Adigüzel, Ragıp, Colak, Naki, Buldurun, Kenan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272191/
https://www.ncbi.nlm.nih.gov/pubmed/26007185
http://dx.doi.org/10.3390/molecules20059309
Descripción
Sumario:Some new Zn(II) and Cu(II) complexes [Cu(L(1))(OAc)(2)]∙H(2)O, [Cu(L(1))(NO(3))H(2)O]∙NO(3)∙3.5H(2)O, [Zn(L(1))(NO(3))(2)]∙4.5H(2)O, [Zn(L(1))(OAc)(2)(H(2)O)(2)]∙3H(2)O, [Cu(2)(L(2))(OAc)(4)]∙2H(2)O∙2DMF, [Cu(L(2))(2)]∙2NO(3)∙1.5DMF∙H(2)O, [Zn(L(2))(2)(NO(3))(2)]∙DMF and [Zn(2)(L(2))(OAc)(4)(H(2)O)(4)]∙5H(2)O; L(1) = 2-[2-(2-methoxyphenyl)hydrazono]cyclohexane-1,3-dione and L(2) = 2-[2-(3-nitrophenyl)hydrazono]cyclohexane-1,3-dione were synthesized and characterized by IR, (1)H-NMR,(13)C-NMR and ultraviolet (UV-Vis.) spectroscopy, elemental analysis, magnetic susceptibility, mass spectrometry and thermogravimetry-differential thermal analysis (TGA-DTA). The synthesized ligands and their complexes were tested for antibacterial activity against Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, and Salmonella typhimurium CCM 583. Some of complexes showed medium-level antibacterial activity against the test bacteria compared with ampicillin.

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