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Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines

Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidi...

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Autores principales: Anh, Hoang Le Tuan, Cuc, Nguyen Thi, Tai, Bui Huu, Yen, Pham Hai, Nhiem, Nguyen Xuan, Thao, Do Thi, Nam, Nguyen Hoai, Van Minh, Chau, Van Kiem, Phan, Kim, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272249/
https://www.ncbi.nlm.nih.gov/pubmed/25587789
http://dx.doi.org/10.3390/molecules20011151
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author Anh, Hoang Le Tuan
Cuc, Nguyen Thi
Tai, Bui Huu
Yen, Pham Hai
Nhiem, Nguyen Xuan
Thao, Do Thi
Nam, Nguyen Hoai
Van Minh, Chau
Van Kiem, Phan
Kim, Young Ho
author_facet Anh, Hoang Le Tuan
Cuc, Nguyen Thi
Tai, Bui Huu
Yen, Pham Hai
Nhiem, Nguyen Xuan
Thao, Do Thi
Nam, Nguyen Hoai
Van Minh, Chau
Van Kiem, Phan
Kim, Young Ho
author_sort Anh, Hoang Le Tuan
collection PubMed
description Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC(50) 44.1 ± 3.6 μg/mL) and breast cancer (IC(50) 32.8 ± 1.4 μg/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents.
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spelling pubmed-62722492018-12-28 Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines Anh, Hoang Le Tuan Cuc, Nguyen Thi Tai, Bui Huu Yen, Pham Hai Nhiem, Nguyen Xuan Thao, Do Thi Nam, Nguyen Hoai Van Minh, Chau Van Kiem, Phan Kim, Young Ho Molecules Article Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC(50) 44.1 ± 3.6 μg/mL) and breast cancer (IC(50) 32.8 ± 1.4 μg/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents. MDPI 2015-01-12 /pmc/articles/PMC6272249/ /pubmed/25587789 http://dx.doi.org/10.3390/molecules20011151 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anh, Hoang Le Tuan
Cuc, Nguyen Thi
Tai, Bui Huu
Yen, Pham Hai
Nhiem, Nguyen Xuan
Thao, Do Thi
Nam, Nguyen Hoai
Van Minh, Chau
Van Kiem, Phan
Kim, Young Ho
Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_full Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_fullStr Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_full_unstemmed Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_short Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
title_sort synthesis of chromonylthiazolidines and their cytotoxicity to human cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272249/
https://www.ncbi.nlm.nih.gov/pubmed/25587789
http://dx.doi.org/10.3390/molecules20011151
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