Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis

Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR ((1)H-(1)H COSY, HMQC and...

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Detalles Bibliográficos
Autores principales: Gong, Jun, Ju, Aichun, Zhou, Dazheng, Li, Dekun, Zhou, Wei, Geng, Wanli, Li, Bing, Li, Li, Liu, Yanjie, He, Ying, Song, Meizhen, Wang, Yunhua, Ye, Zhengliang, Lin, Ruichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272257/
https://www.ncbi.nlm.nih.gov/pubmed/25569522
http://dx.doi.org/10.3390/molecules20010683
Descripción
Sumario:Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR ((1)H-(1)H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H(2)O(2) was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%).

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