Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis

Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR ((1)H-(1)H COSY, HMQC and...

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Autores principales: Gong, Jun, Ju, Aichun, Zhou, Dazheng, Li, Dekun, Zhou, Wei, Geng, Wanli, Li, Bing, Li, Li, Liu, Yanjie, He, Ying, Song, Meizhen, Wang, Yunhua, Ye, Zhengliang, Lin, Ruichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272257/
https://www.ncbi.nlm.nih.gov/pubmed/25569522
http://dx.doi.org/10.3390/molecules20010683
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author Gong, Jun
Ju, Aichun
Zhou, Dazheng
Li, Dekun
Zhou, Wei
Geng, Wanli
Li, Bing
Li, Li
Liu, Yanjie
He, Ying
Song, Meizhen
Wang, Yunhua
Ye, Zhengliang
Lin, Ruichao
author_facet Gong, Jun
Ju, Aichun
Zhou, Dazheng
Li, Dekun
Zhou, Wei
Geng, Wanli
Li, Bing
Li, Li
Liu, Yanjie
He, Ying
Song, Meizhen
Wang, Yunhua
Ye, Zhengliang
Lin, Ruichao
author_sort Gong, Jun
collection PubMed
description Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR ((1)H-(1)H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H(2)O(2) was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%).
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spelling pubmed-62722572018-12-28 Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis Gong, Jun Ju, Aichun Zhou, Dazheng Li, Dekun Zhou, Wei Geng, Wanli Li, Bing Li, Li Liu, Yanjie He, Ying Song, Meizhen Wang, Yunhua Ye, Zhengliang Lin, Ruichao Molecules Article Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR ((1)H-(1)H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H(2)O(2) was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%). MDPI 2015-01-06 /pmc/articles/PMC6272257/ /pubmed/25569522 http://dx.doi.org/10.3390/molecules20010683 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gong, Jun
Ju, Aichun
Zhou, Dazheng
Li, Dekun
Zhou, Wei
Geng, Wanli
Li, Bing
Li, Li
Liu, Yanjie
He, Ying
Song, Meizhen
Wang, Yunhua
Ye, Zhengliang
Lin, Ruichao
Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis
title Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis
title_full Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis
title_fullStr Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis
title_full_unstemmed Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis
title_short Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis
title_sort salvianolic acid y: a new protector of pc12 cells against hydrogen peroxide-induced injury from salvia officinalis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272257/
https://www.ncbi.nlm.nih.gov/pubmed/25569522
http://dx.doi.org/10.3390/molecules20010683
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