An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene...

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Detalles Bibliográficos
Autores principales: Liang, Zizhen, Zhang, Tiantian, Zhang, Xiaoqian, Zhang, Jia, Zhao, Changqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272270/
https://www.ncbi.nlm.nih.gov/pubmed/25594349
http://dx.doi.org/10.3390/molecules20011424
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author Liang, Zizhen
Zhang, Tiantian
Zhang, Xiaoqian
Zhang, Jia
Zhao, Changqi
author_facet Liang, Zizhen
Zhang, Tiantian
Zhang, Xiaoqian
Zhang, Jia
Zhao, Changqi
author_sort Liang, Zizhen
collection PubMed
description Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays.
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spelling pubmed-62722702018-12-28 An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus Liang, Zizhen Zhang, Tiantian Zhang, Xiaoqian Zhang, Jia Zhao, Changqi Molecules Article Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays. MDPI 2015-01-14 /pmc/articles/PMC6272270/ /pubmed/25594349 http://dx.doi.org/10.3390/molecules20011424 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liang, Zizhen
Zhang, Tiantian
Zhang, Xiaoqian
Zhang, Jia
Zhao, Changqi
An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_full An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_fullStr An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_full_unstemmed An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_short An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_sort alkaloid and a steroid from the endophytic fungus aspergillus fumigatus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272270/
https://www.ncbi.nlm.nih.gov/pubmed/25594349
http://dx.doi.org/10.3390/molecules20011424
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