N-Hydroxycinnamide Derivatives of Osthole Ameliorate Hyperglycemia through Activation of AMPK and p38 MAPK

Our previous studies found that osthole markedly reduced blood glucose levels in both db/db and ob/ob mice. To improve the antidiabetic activity of osthole, a series of N-hydroxycinnamide derivatives of osthole were synthesized, and their hypoglycemia activities were examined in vitro and in vivo. B...

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Detalles Bibliográficos
Autores principales: Lee, Wei-Hwa, Wu, Hsueh-Hsia, Huang, Wei-Jan, Li, Yi-Ning, Lin, Ren-Jye, Lin, Shyr-Yi, Liang, Yu-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272315/
https://www.ncbi.nlm.nih.gov/pubmed/25768846
http://dx.doi.org/10.3390/molecules20034516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272315/
https://www.ncbi.nlm.nih.gov/pubmed/25768846
http://dx.doi.org/10.3390/molecules20034516

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