Cargando…

Design, Synthesis and Antitubercular Activity of Certain Nicotinic Acid Hydrazides

Three series of 6-aryl-2-methylnicotinohydrazides 4a–i, N′-arylidene-6-(4-bromophenyl)-2-methylnicotino hydrazides 7a–f, and N′-(un/substituted 2-oxoindolin-3-ylidene)-6-(4-fluorophenyl)-2-methylnicotinohydrazides 8a–c were synthesized and evaluated for their potential in vitro antimycobacterial act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eldehna, Wagdy M., Fares, Mohamed, Abdel-Aziz, Marwa M., Abdel-Aziz, Hatem A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272317/ https://www.ncbi.nlm.nih.gov/pubmed/25988611 http://dx.doi.org/10.3390/molecules20058800

Ejemplares similares

Synthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2015)

Synthesis, Biological Evaluation and Molecular Docking of Certain Sulfones as Potential Nonazole Antifungal Agents
por: Fares, Mohamed, et al.
Publicado: (2016)

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents
por: Eldehna, Wagdy M., et al.
Publicado: (2018)

Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties
por: Eldehna, Wagdy M., et al.
Publicado: (2016)

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents
por: Eldehna, Wagdy M., et al.
Publicado: (2019)

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation
por: El-Naggar, Mohamed, et al.
Publicado: (2018)

Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation
por: El-Naggar, Mohamed, et al.
Publicado: (2018)

Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids
por: Aboul-Fadl, Tarek, et al.
Publicado: (2011)

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation
por: Al-Ansary, Ghada H., et al.
Publicado: (2017)

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres
por: Attia, Mohamed I., et al.
Publicado: (2017)

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment
por: Abo-Ashour, Mahmoud F., et al.
Publicado: (2022)

Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2016)

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells
por: Eldehna, Wagdy M., et al.
Publicado: (2017)

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation
por: Abdelrahman, Mohamed A., et al.
Publicado: (2019)

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
por: Abdel-Aziz, Hatem A, et al.
Publicado: (2017)

Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria
por: Elsayed, Zainab M., et al.
Publicado: (2021)

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
por: Sabt, Ahmed, et al.
Publicado: (2020)

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents
por: Eldehna, Wagdy M., et al.
Publicado: (2017)

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

Synthesis, Biological Evaluation and Computational Studies of New Hydrazide Derivatives Containing 1,3,4-Oxadiazole as Antitubercular Agents
por: Zampieri, Daniele, et al.
Publicado: (2022)

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis
por: Abdelrahman, Mohamed A., et al.
Publicado: (2022)

Computational design and molecular modeling of the interaction of nicotinic acid hydrazide nickel-based complexes with H(2)S gas
por: Louis, Hitler, et al.
Publicado: (2022)

Synthesis Biological Activity of Novel Amino Acid-(N′-Benzoyl) Hydrazide and Amino Acid-(N′-Nicotinoyl) Hydrazide Derivatives
por: Khattab, Sherine N.
Publicado: (2005)

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

New Thiazolyl-Pyrazoline Derivatives as Potential Dual EGFR/HER2 Inhibitors: Design, Synthesis, Anticancer Activity Evaluation and In Silico Study
por: Fakhry, Mariam M., et al.
Publicado: (2023)

Induced in-source fragmentation pattern of certain novel (1Z,2E)-N-(aryl)propanehydrazonoyl chlorides by electrospray mass spectrometry (ESI-MS/MS)
por: Abdelhameed, Ali S, et al.
Publicado: (2013)

Plumbagin analogs-synthesis, characterization, and antitubercular activity
por: Nayak, Nishi, et al.
Publicado: (2014)

Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones
por: Han, M. İhsan, et al.
Publicado: (2023)

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity
por: Al-Rashood, Sara T., et al.
Publicado: (2020)

Design, Synthesis and Evaluation of Antitubercular Activity of Novel Dihydropyridine Containing Imidazolyl Substituent
por: Iman, Maryam, et al.
Publicado: (2015)

Pyrrolyl Pyrazoline Carbaldehydes as Enoyl-ACP Reductase Inhibitors: Design, Synthesis and Antitubercular Activity
por: Dixit, Sheshagiri R., et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity
por: Jarrad, Angie M., et al.
Publicado: (2018)

Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity
por: dos Santos Fernandes, Guilherme Felipe, et al.
Publicado: (2017)

Isonicotinic Acid Hydrazide
Publicado: (1952)

Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides
por: Ugwu, D. I., et al.
Publicado: (2014)

Design, Synthesis and Biological Evaluation of Some Triazole Schiff’s Base Derivatives as Potential Antitubercular Agents
por: Sager, Asma A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_si8p6er05g8i70pp7tpuum9fkl