Discovery of Metal Ions Chelator Quercetin Derivatives with Potent Anti-HCV Activities

Analogues or isosteres of α,γ-diketoacid (DKA) 1a show potent inhibition of hepatitis C virus (HCV) NS5B polymerase through chelation of the two magnesium ions at the active site. The anti-HCV activity of the flavonoid quercetin (2) could partly be attributed to it being a structural mimic of DKAs....

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Detalles Bibliográficos
Autores principales: Zhong, Dongwei, Liu, Mingming, Cao, Yang, Zhu, Yelin, Bian, Shihui, Zhou, Jiayi, Wu, Fengjie, Ryu, Kum-Chol, Zhou, Lu, Ye, Deyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272327/
https://www.ncbi.nlm.nih.gov/pubmed/25913935
http://dx.doi.org/10.3390/molecules20046978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272327/
https://www.ncbi.nlm.nih.gov/pubmed/25913935
http://dx.doi.org/10.3390/molecules20046978

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