Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells

Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver ce...

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Autores principales: Bae, Eun Young, Lee, Seung Woong, Seong, Sin, Cho, Wonjun, Ahn, Jong Seog, Cho, Hyun-Sug
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272334/
https://www.ncbi.nlm.nih.gov/pubmed/25996208
http://dx.doi.org/10.3390/molecules20058988
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author Bae, Eun Young
Lee, Seung Woong
Seong, Sin
Cho, Wonjun
Ahn, Jong Seog
Cho, Hyun-Sug
author_facet Bae, Eun Young
Lee, Seung Woong
Seong, Sin
Cho, Wonjun
Ahn, Jong Seog
Cho, Hyun-Sug
author_sort Bae, Eun Young
collection PubMed
description Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells.
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spelling pubmed-62723342019-01-07 Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells Bae, Eun Young Lee, Seung Woong Seong, Sin Cho, Wonjun Ahn, Jong Seog Cho, Hyun-Sug Molecules Communication Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells. MDPI 2015-05-19 /pmc/articles/PMC6272334/ /pubmed/25996208 http://dx.doi.org/10.3390/molecules20058988 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Bae, Eun Young
Lee, Seung Woong
Seong, Sin
Cho, Wonjun
Ahn, Jong Seog
Cho, Hyun-Sug
Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells
title Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells
title_full Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells
title_fullStr Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells
title_full_unstemmed Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells
title_short Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells
title_sort inhibitory effects of verrucarin a on tunicamycin-induced er stress in fao rat liver cells
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272334/
https://www.ncbi.nlm.nih.gov/pubmed/25996208
http://dx.doi.org/10.3390/molecules20058988
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