Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants

A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antiox...

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Detalles Bibliográficos
Autores principales: López-Frías, Gabriela, Camacho-Dávila, Alejandro A., Chávez-Flores, David, Zaragoza-Galán, Gerardo, Ramos-Sánchez, Víctor H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272376/
https://www.ncbi.nlm.nih.gov/pubmed/26007172
http://dx.doi.org/10.3390/molecules20058654
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author López-Frías, Gabriela
Camacho-Dávila, Alejandro A.
Chávez-Flores, David
Zaragoza-Galán, Gerardo
Ramos-Sánchez, Víctor H.
author_facet López-Frías, Gabriela
Camacho-Dávila, Alejandro A.
Chávez-Flores, David
Zaragoza-Galán, Gerardo
Ramos-Sánchez, Víctor H.
author_sort López-Frías, Gabriela
collection PubMed
description A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases.
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spelling pubmed-62723762019-01-07 Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants López-Frías, Gabriela Camacho-Dávila, Alejandro A. Chávez-Flores, David Zaragoza-Galán, Gerardo Ramos-Sánchez, Víctor H. Molecules Article A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases. MDPI 2015-05-14 /pmc/articles/PMC6272376/ /pubmed/26007172 http://dx.doi.org/10.3390/molecules20058654 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López-Frías, Gabriela
Camacho-Dávila, Alejandro A.
Chávez-Flores, David
Zaragoza-Galán, Gerardo
Ramos-Sánchez, Víctor H.
Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants
title Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants
title_full Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants
title_fullStr Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants
title_full_unstemmed Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants
title_short Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants
title_sort synthesis of a functionalized benzofuran as a synthon for salvianolic acid c analogues as potential ldl antioxidants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272376/
https://www.ncbi.nlm.nih.gov/pubmed/26007172
http://dx.doi.org/10.3390/molecules20058654
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