New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla

The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla, together...

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Detalles Bibliográficos
Autores principales: Hou, Lei, Ding, Gang, Guo, Baolin, Huang, Wenhua, Zhang, Xiaojian, Sun, Zhiyong, Shi, Xiangfen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272386/
https://www.ncbi.nlm.nih.gov/pubmed/25603500
http://dx.doi.org/10.3390/molecules20011551
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author Hou, Lei
Ding, Gang
Guo, Baolin
Huang, Wenhua
Zhang, Xiaojian
Sun, Zhiyong
Shi, Xiangfen
author_facet Hou, Lei
Ding, Gang
Guo, Baolin
Huang, Wenhua
Zhang, Xiaojian
Sun, Zhiyong
Shi, Xiangfen
author_sort Hou, Lei
collection PubMed
description The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla, together with six known compounds 7–12. The inhibitory effects of compounds 1–12 on α-glucosidase were evaluated, and compounds 1, 3 and 6 showed moderate bioactive effect, with inhibitory rates of 10.3%, 10.0% and 11.5%, respectively, compared to the positive control acarbose (41.9%) at 20 µg/mL.
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spelling pubmed-62723862018-12-28 New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla Hou, Lei Ding, Gang Guo, Baolin Huang, Wenhua Zhang, Xiaojian Sun, Zhiyong Shi, Xiangfen Molecules Article The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla, together with six known compounds 7–12. The inhibitory effects of compounds 1–12 on α-glucosidase were evaluated, and compounds 1, 3 and 6 showed moderate bioactive effect, with inhibitory rates of 10.3%, 10.0% and 11.5%, respectively, compared to the positive control acarbose (41.9%) at 20 µg/mL. MDPI 2015-01-16 /pmc/articles/PMC6272386/ /pubmed/25603500 http://dx.doi.org/10.3390/molecules20011551 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hou, Lei
Ding, Gang
Guo, Baolin
Huang, Wenhua
Zhang, Xiaojian
Sun, Zhiyong
Shi, Xiangfen
New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla
title New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla
title_full New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla
title_fullStr New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla
title_full_unstemmed New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla
title_short New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla
title_sort new sesquiterpenoids and a diterpenoid from alpinia oxyphylla
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272386/
https://www.ncbi.nlm.nih.gov/pubmed/25603500
http://dx.doi.org/10.3390/molecules20011551
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