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A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin
In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4′ and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-m...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272442/ https://www.ncbi.nlm.nih.gov/pubmed/26042857 http://dx.doi.org/10.3390/molecules200610184 |
| _version_ | 1783377157663227904 |
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| author | Zhang, Wei Dong, Ze-Xi Gu, Ting Li, Nian-Guang Zhang, Peng-Xuan Wu, Wen-Yu Yu, Shao-Peng Tang, Yu-Ping Yang, Jian-Ping Shi, Zhi-Hao |
| author_facet | Zhang, Wei Dong, Ze-Xi Gu, Ting Li, Nian-Guang Zhang, Peng-Xuan Wu, Wen-Yu Yu, Shao-Peng Tang, Yu-Ping Yang, Jian-Ping Shi, Zhi-Hao |
| author_sort | Zhang, Wei |
| collection | PubMed |
| description | In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4′ and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups. |
| format | Online Article Text |
| id | pubmed-6272442 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62724422018-12-31 A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin Zhang, Wei Dong, Ze-Xi Gu, Ting Li, Nian-Guang Zhang, Peng-Xuan Wu, Wen-Yu Yu, Shao-Peng Tang, Yu-Ping Yang, Jian-Ping Shi, Zhi-Hao Molecules Communication In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4′ and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups. MDPI 2015-06-02 /pmc/articles/PMC6272442/ /pubmed/26042857 http://dx.doi.org/10.3390/molecules200610184 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Communication Zhang, Wei Dong, Ze-Xi Gu, Ting Li, Nian-Guang Zhang, Peng-Xuan Wu, Wen-Yu Yu, Shao-Peng Tang, Yu-Ping Yang, Jian-Ping Shi, Zhi-Hao A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin |
| title | A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin |
| title_full | A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin |
| title_fullStr | A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin |
| title_full_unstemmed | A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin |
| title_short | A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin |
| title_sort | new and efficient synthesis of 6-o-methylscutellarein, the major metabolite of the natural medicine scutellarin |
| topic | Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272442/ https://www.ncbi.nlm.nih.gov/pubmed/26042857 http://dx.doi.org/10.3390/molecules200610184 |
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