Hybrids of Salicylalkylamides and Mannich Bases: Control of the Amide Conformation by Hydrogen Bonding in Solution and in the Solid State

3-Aminomethylation of salicylalkylamides afforded hybrids with a Mannich base. In addition, it triggered the rotation of the amide bond. The observed conformational switch is driven by strong intramolecular hydrogen bonding between the Mannich base and phenolic group. Crystal structure analysis reve...

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Detalles Bibliográficos
Autores principales: Dank, Christian, Kirchknopf, Barbara, Mastalir, Matthias, Kählig, Hanspeter, Felsinger, Susanne, Roller, Alexander, Arion, Vladimir B., Gstach, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272445/
https://www.ncbi.nlm.nih.gov/pubmed/25608856
http://dx.doi.org/10.3390/molecules20011686

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