Cargando…

Effect of Gedunin on Acute Articular Inflammation and Hypernociception in Mice

Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by zymosa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conte, Fernando P., Ferraris, Fausto K., Costa, Thadeu E. M. M., Pacheco, Patricia, Seito, Leonardo N., Verri, Waldiceu A., Cunha, Fernando Q., Penido, Carmen, Henriques, Maria G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272452/ https://www.ncbi.nlm.nih.gov/pubmed/25654532 http://dx.doi.org/10.3390/molecules20022636

Ejemplares similares

Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1β maturation
por: Cunha, Thiago M, et al.
Publicado: (2010)

7-Deacetylgedunin
por: Ravangpai, Warin, et al.
Publicado: (2010)

6α-Acetoxygedunin
por: Hofer, Margit, et al.
Publicado: (2009)

Lithothamnion muelleri Treatment Ameliorates Inflammatory and Hypernociceptive Responses in Antigen-Induced Arthritis in Mice
por: Costa, Vivian V., et al.
Publicado: (2015)

Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway
por: Subramani, Ramadevi, et al.
Publicado: (2016)

Effects of hydroalcoholic extract of Solidago chilensis Meyen on nociception and hypernociception in rodents
por: Malpezzi-Marinho, Elena L. A., et al.
Publicado: (2019)

Biological Activities of Gedunin—A Limonoid from the Meliaceae Family
por: Braga, Teresa M., et al.
Publicado: (2020)

Molecular Property Prediction of Modified Gedunin Using Machine Learning
por: Aly, Mohammed, et al.
Publicado: (2023)

Genistein Antagonizes 17β-Estradiol Effects on Glutamate-Evoked Masseter Muscle Hypernociception in Rats
por: Jie, Hui-Fei, et al.
Publicado: (2018)

Molecular docking analysis of modified gedunin from neem with snake venom enzymes
por: Dagar, Priya, et al.
Publicado: (2021)

Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2/ARE Signaling
por: Chen, Jian-Yu, et al.
Publicado: (2022)

Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice
por: Fattori, Victor, et al.
Publicado: (2018)

In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells
por: Tharmarajah, Luxmiga, et al.
Publicado: (2017)

Harnessing Inflammation Resolution in Arthritis: Current Understanding of Specialized Pro-resolving Lipid Mediators’ Contribution to Arthritis Physiopathology and Future Perspectives
por: Zaninelli, Tiago H., et al.
Publicado: (2021)

Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson’s Disease Rat Model
por: Campos, Ana Carolina P., et al.
Publicado: (2021)

Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice
por: Staurengo-Ferrari, Larissa, et al.
Publicado: (2018)

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation
por: Lourenco-Gonzalez, Yuri, et al.
Publicado: (2019)

Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw
por: Calil, Igor L., et al.
Publicado: (2014)

Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats
por: Zhang, Peng, et al.
Publicado: (2018)

Gedunin and Azadiradione: Human Pancreatic Alpha-Amylase Inhibiting Limonoids from Neem (Azadirachta indica) as Anti-Diabetic Agents
por: Ponnusamy, Sudha, et al.
Publicado: (2015)

Identification of Gedunin from a Phytochemical Depository as a Novel Multidrug Resistance-Bypassing Tubulin Inhibitor of Cancer Cells
por: Khalid, Sami A., et al.
Publicado: (2022)

Stimulation of peripheral Kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway
por: Cunha, Thiago M, et al.
Publicado: (2012)

Editorial: Specialized proresolving mediators: Benefits within and beyond inflammation resolution in cardiometabolic, neurological and psychiatric disorders
por: Sousa, Teresa, et al.
Publicado: (2023)

15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice
por: Ruiz-Miyazawa, Kenji W., et al.
Publicado: (2018)

Editorial: Leukocyte biology and muscle pathology: Leukocytes as potential targets to control muscle inflammation, mass, and pain
por: Hohmann, Miriam S. N., et al.
Publicado: (2023)

Functional relevance of Gedunin as a bona fide ligand of NADPH oxidase 5 and ROS scavenger: An in silico and in vitro assessment in a hyperglycemic RBC model
por: Mazumdar, Suchismita, et al.
Publicado: (2021)

Naringenin: an analgesic and anti-inflammatory citrus flavanone
por: Manchope, Marília F., et al.
Publicado: (2016)

Dietary intervention with narrow-leaved cattail rhizome flour (Typha angustifolia L.) prevents intestinal inflammation in the trinitrobenzenesulphonic acid model of rat colitis
por: Fruet, Andréa Costa, et al.
Publicado: (2012)

Synovial Articular Inflammation of the Knee
Publicado: (1852)

Molecular Mechanisms of Anti-Melanogenic Gedunin Derived from Neem Tree (Azadirachta indica) Using B16F10 Mouse Melanoma Cells and Early-Stage Zebrafish
por: Jeon, Hwang-Ju, et al.
Publicado: (2021)

Intense Acute Swimming Induces Delayed-Onset Muscle Soreness Dependent on Spinal Cord Neuroinflammation
por: Borghi, Sergio M., et al.
Publicado: (2022)

Brief research report: Repurposing pentoxifylline to treat intense acute swimming–Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms
por: Borghi, Sergio M., et al.
Publicado: (2023)

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development
por: Ferraz, Camila R., et al.
Publicado: (2020)

Editorial: Cytokines and Pain
por: Pinto, Larissa G., et al.
Publicado: (2021)

5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality
por: Hohmann, Miriam S. N., et al.
Publicado: (2013)

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice
por: Borghi, Sergio M., et al.
Publicado: (2019)

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A(2): activation of endogenous phospholipases contributes to the pronociceptive effect
por: Dias, Renata Gonçalves, et al.
Publicado: (2017)

Experimental Trypanosoma cruzi Infection Induces Pain in Mice Dependent on Early Spinal Cord Glial Cells and NFκB Activation and Cytokine Production
por: Borghi, Sergio M., et al.
Publicado: (2021)

A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells
por: Nagatomo, Akifumi, et al.
Publicado: (2022)

Nutrition, Inflammation, and Ulceration of Articular Cartilage
por: Barwell, Rd.
Publicado: (1859)

Cannot write session to /tmp/vufind_sessions/sess_hqr74rhimiqelofquju9r5ic4o