New Cytotoxic Sesquiterpenoids from Siegesbeckia glabrescens

Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC...

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Detalles Bibliográficos
Autores principales: Wu, Qian, Li, Hua, Lee, So Yoon, Lee, Hwa Jin, Ryu, Jae-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272480/
https://www.ncbi.nlm.nih.gov/pubmed/25690283
http://dx.doi.org/10.3390/molecules20022850
Descripción
Sumario:Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1–4 showed differential cytotoxic effects on the target cancer cells with IC(50) values in the range of 0.9–33.3 μM.

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