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On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture

Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natur...

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Autores principales: Lind, Tania K., Polcyn, Piotr, Zielinska, Paulina, Cárdenas, Marité, Urbanczyk-Lipkowska, Zofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272501/
https://www.ncbi.nlm.nih.gov/pubmed/25574818
http://dx.doi.org/10.3390/molecules20010738
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author Lind, Tania K.
Polcyn, Piotr
Zielinska, Paulina
Cárdenas, Marité
Urbanczyk-Lipkowska, Zofia
author_facet Lind, Tania K.
Polcyn, Piotr
Zielinska, Paulina
Cárdenas, Marité
Urbanczyk-Lipkowska, Zofia
author_sort Lind, Tania K.
collection PubMed
description Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity.
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spelling pubmed-62725012018-12-28 On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture Lind, Tania K. Polcyn, Piotr Zielinska, Paulina Cárdenas, Marité Urbanczyk-Lipkowska, Zofia Molecules Article Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity. MDPI 2015-01-07 /pmc/articles/PMC6272501/ /pubmed/25574818 http://dx.doi.org/10.3390/molecules20010738 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lind, Tania K.
Polcyn, Piotr
Zielinska, Paulina
Cárdenas, Marité
Urbanczyk-Lipkowska, Zofia
On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
title On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
title_full On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
title_fullStr On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
title_full_unstemmed On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
title_short On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
title_sort on the antimicrobial activity of various peptide-based dendrimers of similar architecture
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272501/
https://www.ncbi.nlm.nih.gov/pubmed/25574818
http://dx.doi.org/10.3390/molecules20010738
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