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On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natur...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272501/ https://www.ncbi.nlm.nih.gov/pubmed/25574818 http://dx.doi.org/10.3390/molecules20010738 |
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author | Lind, Tania K. Polcyn, Piotr Zielinska, Paulina Cárdenas, Marité Urbanczyk-Lipkowska, Zofia |
author_facet | Lind, Tania K. Polcyn, Piotr Zielinska, Paulina Cárdenas, Marité Urbanczyk-Lipkowska, Zofia |
author_sort | Lind, Tania K. |
collection | PubMed |
description | Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity. |
format | Online Article Text |
id | pubmed-6272501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62725012018-12-28 On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture Lind, Tania K. Polcyn, Piotr Zielinska, Paulina Cárdenas, Marité Urbanczyk-Lipkowska, Zofia Molecules Article Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity. MDPI 2015-01-07 /pmc/articles/PMC6272501/ /pubmed/25574818 http://dx.doi.org/10.3390/molecules20010738 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lind, Tania K. Polcyn, Piotr Zielinska, Paulina Cárdenas, Marité Urbanczyk-Lipkowska, Zofia On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture |
title | On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture |
title_full | On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture |
title_fullStr | On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture |
title_full_unstemmed | On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture |
title_short | On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture |
title_sort | on the antimicrobial activity of various peptide-based dendrimers of similar architecture |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272501/ https://www.ncbi.nlm.nih.gov/pubmed/25574818 http://dx.doi.org/10.3390/molecules20010738 |
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