Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties

Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H(2)O] nH(2)O. The relaxivity (R(1)) of these complexes was measured, which turned out to be comparable...

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Autores principales: Ba-Salem, Abdullah O., Ullah, Nisar, Shaikh, M. Nasiruzzaman, Faiz, Mohamed, Ul-Haq, Zaheer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272509/
https://www.ncbi.nlm.nih.gov/pubmed/25939069
http://dx.doi.org/10.3390/molecules20057807
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author Ba-Salem, Abdullah O.
Ullah, Nisar
Shaikh, M. Nasiruzzaman
Faiz, Mohamed
Ul-Haq, Zaheer
author_facet Ba-Salem, Abdullah O.
Ullah, Nisar
Shaikh, M. Nasiruzzaman
Faiz, Mohamed
Ul-Haq, Zaheer
author_sort Ba-Salem, Abdullah O.
collection PubMed
description Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H(2)O] nH(2)O. The relaxivity (R(1)) of these complexes was measured, which turned out to be comparable with that of Omniscan(®), a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, (1)H-NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.
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spelling pubmed-62725092019-01-07 Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties Ba-Salem, Abdullah O. Ullah, Nisar Shaikh, M. Nasiruzzaman Faiz, Mohamed Ul-Haq, Zaheer Molecules Article Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H(2)O] nH(2)O. The relaxivity (R(1)) of these complexes was measured, which turned out to be comparable with that of Omniscan(®), a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, (1)H-NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry. MDPI 2015-04-29 /pmc/articles/PMC6272509/ /pubmed/25939069 http://dx.doi.org/10.3390/molecules20057807 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ba-Salem, Abdullah O.
Ullah, Nisar
Shaikh, M. Nasiruzzaman
Faiz, Mohamed
Ul-Haq, Zaheer
Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties
title Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties
title_full Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties
title_fullStr Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties
title_full_unstemmed Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties
title_short Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties
title_sort gd-complexes of new arylpiperazinyl conjugates of dtpa-bis(amides): synthesis, characterization and magnetic relaxation properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272509/
https://www.ncbi.nlm.nih.gov/pubmed/25939069
http://dx.doi.org/10.3390/molecules20057807
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