Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines

Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(−)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are sup...

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Detalles Bibliográficos
Autores principales: Jia, Yan-Yan, Li, Xiao-Ye, Wang, Ping-An, Wen, Ai-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272547/
https://www.ncbi.nlm.nih.gov/pubmed/25679051
http://dx.doi.org/10.3390/molecules20022922
Descripción
Sumario:Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(−)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, (1)H- and (13)C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics.

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