Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines

Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(−)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are sup...

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Detalles Bibliográficos
Autores principales: Jia, Yan-Yan, Li, Xiao-Ye, Wang, Ping-An, Wen, Ai-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272547/
https://www.ncbi.nlm.nih.gov/pubmed/25679051
http://dx.doi.org/10.3390/molecules20022922
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author Jia, Yan-Yan
Li, Xiao-Ye
Wang, Ping-An
Wen, Ai-Dong
author_facet Jia, Yan-Yan
Li, Xiao-Ye
Wang, Ping-An
Wen, Ai-Dong
author_sort Jia, Yan-Yan
collection PubMed
description Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(−)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, (1)H- and (13)C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics.
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spelling pubmed-62725472018-12-13 Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines Jia, Yan-Yan Li, Xiao-Ye Wang, Ping-An Wen, Ai-Dong Molecules Article Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(−)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, (1)H- and (13)C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics. MDPI 2015-02-11 /pmc/articles/PMC6272547/ /pubmed/25679051 http://dx.doi.org/10.3390/molecules20022922 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jia, Yan-Yan
Li, Xiao-Ye
Wang, Ping-An
Wen, Ai-Dong
Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines
title Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines
title_full Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines
title_fullStr Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines
title_full_unstemmed Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines
title_short Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines
title_sort facile access to unnatural dipeptide-alcohols based on cis-2,5-disubstituted pyrrolidines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272547/
https://www.ncbi.nlm.nih.gov/pubmed/25679051
http://dx.doi.org/10.3390/molecules20022922
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