Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition

An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations a...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Wen-Chang, Kavala, Veerababurao, Shih, Yu-Hsuan, Wang, Yu-Hsuan, Kuo, Chun-Wei, Yang, Tang-Hao, Huang, Chia-Yu, Chiu, Hao-Hsiang, Yao, Ching-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272556/
https://www.ncbi.nlm.nih.gov/pubmed/26076111
http://dx.doi.org/10.3390/molecules200610910
_version_ 1783377184608485376
author Chen, Wen-Chang
Kavala, Veerababurao
Shih, Yu-Hsuan
Wang, Yu-Hsuan
Kuo, Chun-Wei
Yang, Tang-Hao
Huang, Chia-Yu
Chiu, Hao-Hsiang
Yao, Ching-Fa
author_facet Chen, Wen-Chang
Kavala, Veerababurao
Shih, Yu-Hsuan
Wang, Yu-Hsuan
Kuo, Chun-Wei
Yang, Tang-Hao
Huang, Chia-Yu
Chiu, Hao-Hsiang
Yao, Ching-Fa
author_sort Chen, Wen-Chang
collection PubMed
description An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.
format Online
Article
Text
id pubmed-6272556
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62725562018-12-31 Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition Chen, Wen-Chang Kavala, Veerababurao Shih, Yu-Hsuan Wang, Yu-Hsuan Kuo, Chun-Wei Yang, Tang-Hao Huang, Chia-Yu Chiu, Hao-Hsiang Yao, Ching-Fa Molecules Article An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology. MDPI 2015-06-12 /pmc/articles/PMC6272556/ /pubmed/26076111 http://dx.doi.org/10.3390/molecules200610910 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Wen-Chang
Kavala, Veerababurao
Shih, Yu-Hsuan
Wang, Yu-Hsuan
Kuo, Chun-Wei
Yang, Tang-Hao
Huang, Chia-Yu
Chiu, Hao-Hsiang
Yao, Ching-Fa
Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_full Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_fullStr Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_full_unstemmed Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_short Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_sort synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272556/
https://www.ncbi.nlm.nih.gov/pubmed/26076111
http://dx.doi.org/10.3390/molecules200610910
work_keys_str_mv AT chenwenchang synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT kavalaveerababurao synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT shihyuhsuan synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT wangyuhsuan synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT kuochunwei synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT yangtanghao synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT huangchiayu synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT chiuhaohsiang synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition
AT yaochingfa synthesisofbicyclicisoxazolesandisoxazolinesviaintramolecularnitrileoxidecycloaddition

Ejemplares similares