Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners

Several series of novel substituted thienothiophene derivatives were synthesized by reacting the synthone 1 with different reagents. The newly synthesized compounds were characterized by means of different spectroscopic methods such as IR, NMR, mass spectrometry and by elemental analyses. The new co...

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Autores principales: Mabkhot, Yahia N., Aldawsari, Fahad D., Al-Showiman, Salim S., Barakat, Assem, Ben Hadda, Taibi, Mubarak, Mohammad S., Naz, Sehrish, Ul-Haq, Zaheer, Rauf, Abdur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272574/
https://www.ncbi.nlm.nih.gov/pubmed/25621424
http://dx.doi.org/10.3390/molecules20021824
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author Mabkhot, Yahia N.
Aldawsari, Fahad D.
Al-Showiman, Salim S.
Barakat, Assem
Ben Hadda, Taibi
Mubarak, Mohammad S.
Naz, Sehrish
Ul-Haq, Zaheer
Rauf, Abdur
author_facet Mabkhot, Yahia N.
Aldawsari, Fahad D.
Al-Showiman, Salim S.
Barakat, Assem
Ben Hadda, Taibi
Mubarak, Mohammad S.
Naz, Sehrish
Ul-Haq, Zaheer
Rauf, Abdur
author_sort Mabkhot, Yahia N.
collection PubMed
description Several series of novel substituted thienothiophene derivatives were synthesized by reacting the synthone 1 with different reagents. The newly synthesized compounds were characterized by means of different spectroscopic methods such as IR, NMR, mass spectrometry and by elemental analyses. The new compounds displayed significant activity against both Gram-positive and Gram negative bacteria, in addition to fungi. Molecular docking and POM analyses show the crucial role and impact of substituents on bioactivity and indicate the unfavorable structural parameters in actual drug design: more substitution doesn’t guaranty more efficiency in bioactivity.
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spelling pubmed-62725742018-12-13 Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners Mabkhot, Yahia N. Aldawsari, Fahad D. Al-Showiman, Salim S. Barakat, Assem Ben Hadda, Taibi Mubarak, Mohammad S. Naz, Sehrish Ul-Haq, Zaheer Rauf, Abdur Molecules Article Several series of novel substituted thienothiophene derivatives were synthesized by reacting the synthone 1 with different reagents. The newly synthesized compounds were characterized by means of different spectroscopic methods such as IR, NMR, mass spectrometry and by elemental analyses. The new compounds displayed significant activity against both Gram-positive and Gram negative bacteria, in addition to fungi. Molecular docking and POM analyses show the crucial role and impact of substituents on bioactivity and indicate the unfavorable structural parameters in actual drug design: more substitution doesn’t guaranty more efficiency in bioactivity. MDPI 2015-01-23 /pmc/articles/PMC6272574/ /pubmed/25621424 http://dx.doi.org/10.3390/molecules20021824 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mabkhot, Yahia N.
Aldawsari, Fahad D.
Al-Showiman, Salim S.
Barakat, Assem
Ben Hadda, Taibi
Mubarak, Mohammad S.
Naz, Sehrish
Ul-Haq, Zaheer
Rauf, Abdur
Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
title Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
title_full Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
title_fullStr Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
title_full_unstemmed Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
title_short Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
title_sort synthesis, bioactivity, molecular docking and pom analyses of novel substituted thieno[2,3-b]thiophenes and related congeners
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272574/
https://www.ncbi.nlm.nih.gov/pubmed/25621424
http://dx.doi.org/10.3390/molecules20021824
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