Cargando…

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni

Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glaser, Jan, Schurigt, Uta, Suzuki, Brian M., Caffrey, Conor R., Holzgrabe, Ulrike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272620/ https://www.ncbi.nlm.nih.gov/pubmed/26076109 http://dx.doi.org/10.3390/molecules200610873

Ejemplares similares

Cinnamic Acid Bornyl Ester Derivatives from Valeriana wallichii Exhibit Antileishmanial In Vivo Activity in Leishmania major-Infected BALB/c Mice
por: Masic, Anita, et al.
Publicado: (2015)

Role of arginase in killing of schistosomula of schistosoma mansoni
por: Olds, GR, et al.
Publicado: (1980)

Antibody responses to Schistosoma mansoni schistosomula antigens
por: Egesa, Moses, et al.
Publicado: (2018)

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives
por: Tian, Yuxin, et al.
Publicado: (2016)

RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening
por: Štefanić, Saša, et al.
Publicado: (2010)

Creatininium cinnamate
por: Ali, A. Jahubar, et al.
Publicado: (2011)

Complement-mediated killing of schistosomula of Schistosoma mansoni by rat eosinophils in vitro
Publicado: (1978)

Schistosomula of Schistosoma mansoni clear concanavalin A from their surface by sloughing
Publicado: (1982)

Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni
Publicado: (1978)

Transcriptional Changes in Schistosoma mansoni during Early Schistosomula Development and in the Presence of Erythrocytes
por: Gobert, Geoffrey N., et al.
Publicado: (2010)

Comparative Study of Transcriptome Profiles of Mechanical- and Skin-Transformed Schistosoma mansoni Schistosomula
por: Protasio, Anna V., et al.
Publicado: (2013)

Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays
por: Panic, Gordana, et al.
Publicado: (2015)

Structure−Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents
por: Bernal, Freddy A., et al.
Publicado: (2019)

A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues
por: Bernal, Freddy A., et al.
Publicado: (2019)

Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms
por: Silva-Moraes, Vanessa, et al.
Publicado: (2013)

Schistosoma mansoni schistosomula antigens induce Th1/Pro‐inflammatory cytokine responses
por: Egesa, Moses, et al.
Publicado: (2018)

In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
por: Pereira, Adriana S. A., et al.
Publicado: (2019)

Cinnamate-based DNA photolithography
por: Feng, Lang, et al.
Publicado: (2013)

Multifunctional Cinnamic Acid Derivatives
por: Peperidou, Aikaterini, et al.
Publicado: (2017)

Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors
por: Doiron, Jérémie A., et al.
Publicado: (2014)

Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
por: Ruan, Ban-Feng, et al.
Publicado: (2017)

Methoxylated Cinnamic Esters with Antiproliferative and Antimetastatic Effects on Human Lung Adenocarcinoma Cells
por: Sampaio, João Graciano, et al.
Publicado: (2023)

Human erythrocytes adhering to schistosomula of Schistosoma mansoni lyse and fail to transfer membrane components to the parasite
Publicado: (1985)

Interactions between human eosinophils and schistosomula of schistosoma mansoni. II. The mechanism of irreversible eosinophil adherence
por: Butterworth, AE, et al.
Publicado: (1979)

Loss of covalently labeled glycoproteins and glycolipids from the surface of newly transformed schistosomula of Schistosoma mansoni
Publicado: (1982)

Mechanisms for Improving Hepatic Glucolipid Metabolism by Cinnamic Acid and Cinnamic Aldehyde: An Insight Provided by Multi-Omics
por: Wu, You, et al.
Publicado: (2022)

Correction: design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors
por: Sheng, Zhaojun, et al.
Publicado: (2018)

Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice
por: Zanetti, Micheli, et al.
Publicado: (2021)

Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid–Eugenol Esters
por: Li, Jianping, et al.
Publicado: (2023)

Multitarget Molecular Hybrids of Cinnamic Acids
por: Peperidou, Aikaterini, et al.
Publicado: (2014)

Cinnamic Acid Derivatives and Their Biological Efficacy
por: Ruwizhi, Ngonidzashe, et al.
Publicado: (2020)

Human neutrophils endocytose multivalent ligands from the surface of schistosomula of Schistosoma mansoni before membrane fusion
Publicado: (1982)

Semisynthesis and Pesticidal Activities of Novel Cholesterol Ester Derivatives Containing Cinnamic Acid-like Fragments
por: Lu, Rongfei, et al.
Publicado: (2022)

Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils
Publicado: (1977)

Comparative sequence analysis reveals regulation of genes in developing schistosomula of Schistosoma mansoni exposed to host portal serum
por: Jeremias, Wander de Jesus, et al.
Publicado: (2017)

Evaluation of schistosomula crude antigen (SCA) as a diagnostic tool for Schistosoma mansoni in low endemic human population
por: Oyeyemi, Oyetunde Timothy, et al.
Publicado: (2021)

Crystal structure of morpholin-4-ium cinnamate
por: Smith, Graham
Publicado: (2015)

Multi-modal mechanophores based on cinnamate dimers
por: Zhang, Huan, et al.
Publicado: (2017)

Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives
por: Malheiro, Joana F., et al.
Publicado: (2019)

Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives
por: Nouni, Christina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j9k8tkljg8elpiudsgc9atd3ie