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Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector

In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. T...

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Detalles Bibliográficos
Autores principales: Murayama, Kodai, Ishikawa, Daitaro, Genkawa, Takuma, Sugino, Hiroyuki, Komiyama, Makoto, Ozaki, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272623/
https://www.ncbi.nlm.nih.gov/pubmed/25741896
http://dx.doi.org/10.3390/molecules20034007
Descripción
Sumario:In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis.