Cargando…
Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector
In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. T...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272623/ https://www.ncbi.nlm.nih.gov/pubmed/25741896 http://dx.doi.org/10.3390/molecules20034007 |
_version_ | 1783377199745728512 |
---|---|
author | Murayama, Kodai Ishikawa, Daitaro Genkawa, Takuma Sugino, Hiroyuki Komiyama, Makoto Ozaki, Yukihiro |
author_facet | Murayama, Kodai Ishikawa, Daitaro Genkawa, Takuma Sugino, Hiroyuki Komiyama, Makoto Ozaki, Yukihiro |
author_sort | Murayama, Kodai |
collection | PubMed |
description | In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis. |
format | Online Article Text |
id | pubmed-6272623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62726232018-12-31 Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector Murayama, Kodai Ishikawa, Daitaro Genkawa, Takuma Sugino, Hiroyuki Komiyama, Makoto Ozaki, Yukihiro Molecules Article In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis. MDPI 2015-03-03 /pmc/articles/PMC6272623/ /pubmed/25741896 http://dx.doi.org/10.3390/molecules20034007 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Murayama, Kodai Ishikawa, Daitaro Genkawa, Takuma Sugino, Hiroyuki Komiyama, Makoto Ozaki, Yukihiro Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector |
title | Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector |
title_full | Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector |
title_fullStr | Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector |
title_full_unstemmed | Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector |
title_short | Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector |
title_sort | image monitoring of pharmaceutical blending processes and the determination of an end point by using a portable near-infrared imaging device based on a polychromator-type near-infrared spectrometer with a high-speed and high-resolution photo diode array detector |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272623/ https://www.ncbi.nlm.nih.gov/pubmed/25741896 http://dx.doi.org/10.3390/molecules20034007 |
work_keys_str_mv | AT murayamakodai imagemonitoringofpharmaceuticalblendingprocessesandthedeterminationofanendpointbyusingaportablenearinfraredimagingdevicebasedonapolychromatortypenearinfraredspectrometerwithahighspeedandhighresolutionphotodiodearraydetector AT ishikawadaitaro imagemonitoringofpharmaceuticalblendingprocessesandthedeterminationofanendpointbyusingaportablenearinfraredimagingdevicebasedonapolychromatortypenearinfraredspectrometerwithahighspeedandhighresolutionphotodiodearraydetector AT genkawatakuma imagemonitoringofpharmaceuticalblendingprocessesandthedeterminationofanendpointbyusingaportablenearinfraredimagingdevicebasedonapolychromatortypenearinfraredspectrometerwithahighspeedandhighresolutionphotodiodearraydetector AT suginohiroyuki imagemonitoringofpharmaceuticalblendingprocessesandthedeterminationofanendpointbyusingaportablenearinfraredimagingdevicebasedonapolychromatortypenearinfraredspectrometerwithahighspeedandhighresolutionphotodiodearraydetector AT komiyamamakoto imagemonitoringofpharmaceuticalblendingprocessesandthedeterminationofanendpointbyusingaportablenearinfraredimagingdevicebasedonapolychromatortypenearinfraredspectrometerwithahighspeedandhighresolutionphotodiodearraydetector AT ozakiyukihiro imagemonitoringofpharmaceuticalblendingprocessesandthedeterminationofanendpointbyusingaportablenearinfraredimagingdevicebasedonapolychromatortypenearinfraredspectrometerwithahighspeedandhighresolutionphotodiodearraydetector |