Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase

The combination of the ionic liquid co-lyophilized lipase and microwave irradiation was used to improve enzyme performance in enantioselective esterification of α-lipoic acid. Effects of various reaction conditions on enzyme activity and enantioselectivity were investigated. Under optimal condition,...

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Autores principales: Liu, Ning, Wang, Lei, Wang, Zhi, Jiang, Liyan, Wu, Zhuofu, Yue, Hong, Xie, Xiaona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272624/
https://www.ncbi.nlm.nih.gov/pubmed/26035096
http://dx.doi.org/10.3390/molecules20069949
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author Liu, Ning
Wang, Lei
Wang, Zhi
Jiang, Liyan
Wu, Zhuofu
Yue, Hong
Xie, Xiaona
author_facet Liu, Ning
Wang, Lei
Wang, Zhi
Jiang, Liyan
Wu, Zhuofu
Yue, Hong
Xie, Xiaona
author_sort Liu, Ning
collection PubMed
description The combination of the ionic liquid co-lyophilized lipase and microwave irradiation was used to improve enzyme performance in enantioselective esterification of α-lipoic acid. Effects of various reaction conditions on enzyme activity and enantioselectivity were investigated. Under optimal condition, the highest enantioselectivity (E = 41.2) was observed with a high enzyme activity (178.1 μmol/h/mg) when using the ionic liquid co-lyophilized lipase with microwave assistance. Furthermore, the ionic liquid co-lyophilized lipase exhibited excellent reusability under low power microwave.
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spelling pubmed-62726242018-12-31 Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase Liu, Ning Wang, Lei Wang, Zhi Jiang, Liyan Wu, Zhuofu Yue, Hong Xie, Xiaona Molecules Article The combination of the ionic liquid co-lyophilized lipase and microwave irradiation was used to improve enzyme performance in enantioselective esterification of α-lipoic acid. Effects of various reaction conditions on enzyme activity and enantioselectivity were investigated. Under optimal condition, the highest enantioselectivity (E = 41.2) was observed with a high enzyme activity (178.1 μmol/h/mg) when using the ionic liquid co-lyophilized lipase with microwave assistance. Furthermore, the ionic liquid co-lyophilized lipase exhibited excellent reusability under low power microwave. MDPI 2015-05-29 /pmc/articles/PMC6272624/ /pubmed/26035096 http://dx.doi.org/10.3390/molecules20069949 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Ning
Wang, Lei
Wang, Zhi
Jiang, Liyan
Wu, Zhuofu
Yue, Hong
Xie, Xiaona
Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase
title Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase
title_full Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase
title_fullStr Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase
title_full_unstemmed Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase
title_short Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase
title_sort microwave-assisted resolution of α-lipoic acid catalyzed by an ionic liquid co-lyophilized lipase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272624/
https://www.ncbi.nlm.nih.gov/pubmed/26035096
http://dx.doi.org/10.3390/molecules20069949
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