Computational Study of Symmetric Methylation on Histone Arginine Catalyzed by Protein Arginine Methyltransferase PRMT5 through QM/MM MD and Free Energy Simulations

Protein arginine methyltransferases (PRMTs) catalyze the transfer of the methyl group from S-adenosyl-l-methionine (AdoMet) to arginine residues. There are three types of PRMTs (I, II and III) that produce different methylation products, including asymmetric dimethylarginine (ADMA), symmetric dimeth...

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Detalles Bibliográficos
Autores principales: Yue, Yufei, Chu, Yuzhuo, Guo, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272650/
https://www.ncbi.nlm.nih.gov/pubmed/26035101
http://dx.doi.org/10.3390/molecules200610032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272650/
https://www.ncbi.nlm.nih.gov/pubmed/26035101
http://dx.doi.org/10.3390/molecules200610032

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