Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for...

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Detalles Bibliográficos
Autores principales: Legarda-Ceballos, Ana L., del Olmo, Esther, López-Abán, Julio, Escarcena, Ricardo, Bustos, Luis A., Fonseca-Berzal, Cristina, Gómez-Barrio, Alicia, Dib, Juan C., San Feliciano, Arturo, Muro, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272662/
https://www.ncbi.nlm.nih.gov/pubmed/26111182
http://dx.doi.org/10.3390/molecules200611554
Descripción
Sumario:Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC(50) = 0.6 µM), with a selectivity index of 54.

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