Cargando…
Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272662/ https://www.ncbi.nlm.nih.gov/pubmed/26111182 http://dx.doi.org/10.3390/molecules200611554 |
| _version_ | 1783377208908185600 |
|---|---|
| author | Legarda-Ceballos, Ana L. del Olmo, Esther López-Abán, Julio Escarcena, Ricardo Bustos, Luis A. Fonseca-Berzal, Cristina Gómez-Barrio, Alicia Dib, Juan C. San Feliciano, Arturo Muro, Antonio |
| author_facet | Legarda-Ceballos, Ana L. del Olmo, Esther López-Abán, Julio Escarcena, Ricardo Bustos, Luis A. Fonseca-Berzal, Cristina Gómez-Barrio, Alicia Dib, Juan C. San Feliciano, Arturo Muro, Antonio |
| author_sort | Legarda-Ceballos, Ana L. |
| collection | PubMed |
| description | Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC(50) = 0.6 µM), with a selectivity index of 54. |
| format | Online Article Text |
| id | pubmed-6272662 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62726622018-12-31 Trypanocidal Activity of Long Chain Diamines and Aminoalcohols Legarda-Ceballos, Ana L. del Olmo, Esther López-Abán, Julio Escarcena, Ricardo Bustos, Luis A. Fonseca-Berzal, Cristina Gómez-Barrio, Alicia Dib, Juan C. San Feliciano, Arturo Muro, Antonio Molecules Article Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC(50) = 0.6 µM), with a selectivity index of 54. MDPI 2015-06-23 /pmc/articles/PMC6272662/ /pubmed/26111182 http://dx.doi.org/10.3390/molecules200611554 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Legarda-Ceballos, Ana L. del Olmo, Esther López-Abán, Julio Escarcena, Ricardo Bustos, Luis A. Fonseca-Berzal, Cristina Gómez-Barrio, Alicia Dib, Juan C. San Feliciano, Arturo Muro, Antonio Trypanocidal Activity of Long Chain Diamines and Aminoalcohols |
| title | Trypanocidal Activity of Long Chain Diamines and Aminoalcohols |
| title_full | Trypanocidal Activity of Long Chain Diamines and Aminoalcohols |
| title_fullStr | Trypanocidal Activity of Long Chain Diamines and Aminoalcohols |
| title_full_unstemmed | Trypanocidal Activity of Long Chain Diamines and Aminoalcohols |
| title_short | Trypanocidal Activity of Long Chain Diamines and Aminoalcohols |
| title_sort | trypanocidal activity of long chain diamines and aminoalcohols |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272662/ https://www.ncbi.nlm.nih.gov/pubmed/26111182 http://dx.doi.org/10.3390/molecules200611554 |
| work_keys_str_mv | AT legardaceballosanal trypanocidalactivityoflongchaindiaminesandaminoalcohols AT delolmoesther trypanocidalactivityoflongchaindiaminesandaminoalcohols AT lopezabanjulio trypanocidalactivityoflongchaindiaminesandaminoalcohols AT escarcenaricardo trypanocidalactivityoflongchaindiaminesandaminoalcohols AT bustosluisa trypanocidalactivityoflongchaindiaminesandaminoalcohols AT fonsecaberzalcristina trypanocidalactivityoflongchaindiaminesandaminoalcohols AT gomezbarrioalicia trypanocidalactivityoflongchaindiaminesandaminoalcohols AT dibjuanc trypanocidalactivityoflongchaindiaminesandaminoalcohols AT sanfelicianoarturo trypanocidalactivityoflongchaindiaminesandaminoalcohols AT muroantonio trypanocidalactivityoflongchaindiaminesandaminoalcohols |