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Theory and Applications of Covalent Docking in Drug Discovery: Merits and Pitfalls

The present art of drug discovery and design of new drugs is based on suicidal irreversible inhibitors. Covalent inhibition is the strategy that is used to achieve irreversible inhibition. Irreversible inhibitors interact with their targets in a time-dependent fashion, and the reaction proceeds to c...

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Detalles Bibliográficos
Autores principales:	Kumalo, Hezekiel Mathambo, Bhakat, Soumendranath, Soliman, Mahmoud E. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272664/ https://www.ncbi.nlm.nih.gov/pubmed/25633330 http://dx.doi.org/10.3390/molecules20021984

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