Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity

By implementing a common and industrially used method, 30 compounds which are structurally related to geranyl acetone, nerolidol, farnesal, farnesol and farnesyl acetate were obtained. Their antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichi...

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Autores principales: Bonikowski, Radosław, Świtakowska, Paulina, Sienkiewicz, Monika, Zakłos-Szyda, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272674/
https://www.ncbi.nlm.nih.gov/pubmed/26096434
http://dx.doi.org/10.3390/molecules200611272
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author Bonikowski, Radosław
Świtakowska, Paulina
Sienkiewicz, Monika
Zakłos-Szyda, Małgorzata
author_facet Bonikowski, Radosław
Świtakowska, Paulina
Sienkiewicz, Monika
Zakłos-Szyda, Małgorzata
author_sort Bonikowski, Radosław
collection PubMed
description By implementing a common and industrially used method, 30 compounds which are structurally related to geranyl acetone, nerolidol, farnesal, farnesol and farnesyl acetate were obtained. Their antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii bacteria was investigated. Pharmacophore models were proposed based on the obtained results and 3D QSAR modelling. Cytotoxic effects against mainly human immortalised and normal cell lines of different origin (malignant melanoma MeWo, colorectal adenocarcinoma HT29, promyelocytic leukemia HL60, gingival fibroblasts HFIG, skin keratinocytes HaCaT and rat small intestine epithelium IEC6) were examined. The odour descriptions of newly synthesised compounds are given.
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spelling pubmed-62726742018-12-31 Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity Bonikowski, Radosław Świtakowska, Paulina Sienkiewicz, Monika Zakłos-Szyda, Małgorzata Molecules Article By implementing a common and industrially used method, 30 compounds which are structurally related to geranyl acetone, nerolidol, farnesal, farnesol and farnesyl acetate were obtained. Their antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii bacteria was investigated. Pharmacophore models were proposed based on the obtained results and 3D QSAR modelling. Cytotoxic effects against mainly human immortalised and normal cell lines of different origin (malignant melanoma MeWo, colorectal adenocarcinoma HT29, promyelocytic leukemia HL60, gingival fibroblasts HFIG, skin keratinocytes HaCaT and rat small intestine epithelium IEC6) were examined. The odour descriptions of newly synthesised compounds are given. MDPI 2015-06-18 /pmc/articles/PMC6272674/ /pubmed/26096434 http://dx.doi.org/10.3390/molecules200611272 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bonikowski, Radosław
Świtakowska, Paulina
Sienkiewicz, Monika
Zakłos-Szyda, Małgorzata
Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity
title Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity
title_full Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity
title_fullStr Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity
title_full_unstemmed Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity
title_short Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity
title_sort selected compounds structurally related to acyclic sesquiterpenoids and their antibacterial and cytotoxic activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272674/
https://www.ncbi.nlm.nih.gov/pubmed/26096434
http://dx.doi.org/10.3390/molecules200611272
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