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Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics

Despite the great promise of nucleic acid aptamers in the areas of diagnostics and therapeutics for their facile in vitro development, lack of immunogenicity and other desirable properties, few truly successful aptamer-based products exist in the clinical or other markets. Core reasons for these com...

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Autor principal: Bruno, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272696/
https://www.ncbi.nlm.nih.gov/pubmed/25913927
http://dx.doi.org/10.3390/molecules20046866
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author Bruno, John G.
author_facet Bruno, John G.
author_sort Bruno, John G.
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description Despite the great promise of nucleic acid aptamers in the areas of diagnostics and therapeutics for their facile in vitro development, lack of immunogenicity and other desirable properties, few truly successful aptamer-based products exist in the clinical or other markets. Core reasons for these commercial deficiencies probably stem from industrial commitment to antibodies including a huge financial investment in humanized monoclonal antibodies and a general ignorance about aptamers and their performance among the research and development community. Given the early failures of some strong commercial efforts to gain government approval and bring aptamer-based products to market, it may seem that aptamers are doomed to take a backseat to antibodies forever. However, the key advantages of aptamers over antibodies coupled with niche market needs that only aptamers can fill and more recent published data still point to a bright commercial future for aptamers in areas such as infectious disease and cancer diagnostics and therapeutics. As more researchers and entrepreneurs become familiar with aptamers, it seems inevitable that aptamers will at least be considered for expanded roles in diagnostics and therapeutics. This review also examines new aptamer modifications and attempts to predict new aptamer applications that could revolutionize biomedical technology in the future and lead to marketed products.
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spelling pubmed-62726962018-12-03 Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics Bruno, John G. Molecules Review Despite the great promise of nucleic acid aptamers in the areas of diagnostics and therapeutics for their facile in vitro development, lack of immunogenicity and other desirable properties, few truly successful aptamer-based products exist in the clinical or other markets. Core reasons for these commercial deficiencies probably stem from industrial commitment to antibodies including a huge financial investment in humanized monoclonal antibodies and a general ignorance about aptamers and their performance among the research and development community. Given the early failures of some strong commercial efforts to gain government approval and bring aptamer-based products to market, it may seem that aptamers are doomed to take a backseat to antibodies forever. However, the key advantages of aptamers over antibodies coupled with niche market needs that only aptamers can fill and more recent published data still point to a bright commercial future for aptamers in areas such as infectious disease and cancer diagnostics and therapeutics. As more researchers and entrepreneurs become familiar with aptamers, it seems inevitable that aptamers will at least be considered for expanded roles in diagnostics and therapeutics. This review also examines new aptamer modifications and attempts to predict new aptamer applications that could revolutionize biomedical technology in the future and lead to marketed products. MDPI 2015-04-16 /pmc/articles/PMC6272696/ /pubmed/25913927 http://dx.doi.org/10.3390/molecules20046866 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bruno, John G.
Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics
title Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics
title_full Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics
title_fullStr Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics
title_full_unstemmed Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics
title_short Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics
title_sort predicting the uncertain future of aptamer-based diagnostics and therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272696/
https://www.ncbi.nlm.nih.gov/pubmed/25913927
http://dx.doi.org/10.3390/molecules20046866
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