Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound

We describe the multigram synthesis and in vivo efficacy studies of a donepezil‒huprine hybrid that has been found to display a promising in vitro multitarget profile of interest for the treatment of Alzheimer’s disease (AD). Its synthesis features as the key step a novel multigram preparative chrom...

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Detalles Bibliográficos
Autores principales: Sola, Irene, Viayna, Elisabet, Gómez, Tània, Galdeano, Carles, Cassina, Matteo, Camps, Pelayo, Romeo, Margherita, Diomede, Luisa, Salmona, Mario, Franco, Pilar, Schaeffer, Mireille, Colantuono, Diego, Robin, David, Brunner, Daniela, Taub, Nicole, Hutter-Paier, Birgit, Muñoz-Torrero, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272704/
https://www.ncbi.nlm.nih.gov/pubmed/25764491
http://dx.doi.org/10.3390/molecules20034492

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